论文部分内容阅读
目的 :探讨脑胶质瘤术后敏感药物间质化疗联合增敏放疗的临床疗效。方法 :恶性脑胶质瘤 15 8例最大限度地全切或次全切 ,术中于瘤残腔内安置化疗囊 ,术后第 2 ,4,6,8周分别注射一次经MTT法筛选出的敏感疗药物ACNU ,BCNU ,VM2 6,DDP ,5 FU ,MMC ,ACR ,ADM和BLM中的一种 ,生理盐水 2～ 4mL稀释后穿刺化疗囊 ,微泵调控注射 6～ 8h。同时行全脑增敏放疗 ,2Gy/次 ,5次 /周 ,总量 5 5～ 60Gy。以后成倍延长间质化疗时间间隔。结果 :15 8例平均随访 3年 ,无明显不良反应 ,其中显效 (肿瘤完全消失 ) 46例 ,有效 (肿瘤部分消失 ) 78例 ,无变化 19例 ,恶化 15例。平均生存时间 66周 ,总有效率 78 5 %。结论 :手术后敏感药物间质化疗联合增敏放疗治疗恶性脑胶质瘤安全显效
Objective: To investigate the clinical efficacy of sensitized drug-stroma chemotherapy combined with sensitization and radiation therapy after glioma surgery. METHODS: A total of 15 8 cases of malignant gliomas were excised or subtotally resected. Chemotherapy capsules were placed in the residual tumor during the operation. The cells were injected once, 2, 4, 6 and 8 weeks after the operation by MTT Of sensitive drugs ACNU, BCNU, VM2 6, DDP, 5 FU, MMC, ACR, ADM and BLM in one, 2 ~ 4mL normal saline puncture after chemotherapy capsule, micro-pump control injection 6 ~ 8h. At the same time the whole brain sensitization radiotherapy, 2Gy / time, 5 times / week, a total of 5 5 ~ 60Gy. Subsequent extension of interstitial chemotherapy interval. Results: Fifteen cases were followed up for an average of 3 years without obvious adverse reactions. Among them, 46 were effective (complete disappearance of tumor), 78 were effective (partial disappearance of tumor), 19 were unchanged, and 15 were worsened. The average survival time was 66 weeks, with a total effective rate of 78.5%. Conclusion: Postoperative sensitized drug mesenchymal chemotherapy combined with sensitization and radiation therapy is effective in treating malignant glioma