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目的:探讨透明质酸钠对剖宫产产妇血清基质金属蛋白酶9(MMP-9)、一氧化氮(NO)、层粘蛋白(LN)及炎性因子的影响。方法:选取2010年11月-2012年10月于该院进行常规处理的45例剖宫产产妇为对照组,并将同一时期采用透明质酸钠处理的45例产妇选为观察组,然后将两组产妇产前与产后不同时间的血清MMP-9、NO、LN及炎性因子水平进行比较。结果:观察组产后不同时间的血清MMP-9高于对照组,NO、LN及炎性因子水平低于对照组,P值均<0.05,均有统计学差异。结论:透明质酸钠对剖宫产产妇血清MMP-9、NO、LN及炎性因子的影响较为明显,对于控制粘连及感染的发生均有积极的临床作用。
Objective: To investigate the effects of sodium hyaluronate on serum MMP-9, NO, LN and inflammatory cytokines in cesarean section. METHODS: Forty-five cesarean section women who underwent conventional treatment in the hospital from November 2010 to October 2012 were selected as the control group. Forty-five women treated with sodium hyaluronate in the same period were selected as observation group, The levels of serum MMP-9, NO, LN and inflammatory cytokines in preterm and postnatal period were compared between two groups. Results: The levels of serum MMP-9 in the observation group were significantly higher than those in the control group at different times of postpartum. The levels of NO, LN and inflammatory cytokines in the observation group were lower than those in the control group (P <0.05). CONCLUSION: Sodium hyaluronate has a significant effect on serum MMP-9, NO, LN and inflammatory cytokines in cesarean section, which has a positive clinical effect on the prevention of adhesion and infection.