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发明摘要专利披露了反式-4-氨基-环己基醋酸乙酯盐酸盐的制备过程:a)4-硝基苯醋酸在质子溶剂中加氢反应,反应条件是温度40~50℃,催化剂钯/碳(钯载于碳上),过压0.1~0.6巴;b)步骤a)得到的产物4-氨基苯醋酸进一步加氢反应,反应条件是温度50~60℃,过压1~4巴;c)加热步骤b)得到的4-氨基-环己基醋酸,在盐酸乙醇中回流1~3小时,并且如果需要在除去溶剂后,将乙腈加入得到的残留物中,然后蒸馏掉。
SUMMARY OF THE INVENTION The patent discloses the preparation of trans-4-amino-cyclohexyl ethyl acetate hydrochloride: a) hydrogenation of 4-nitrophenylacetic acid in a protic solvent under the conditions of a temperature of 40 to 50 ° C, a catalyst Palladium on carbon (palladium on carbon) overpressure of 0.1 to 0.6 bar; b) further hydrogenating the product 4-aminophenylacetic acid obtained in step a) under the conditions of a temperature of 50 to 60 DEG C and an overpressure of 1 to 4 C) heating the 4-amino-cyclohexyl acetic acid obtained in step b), refluxing for 1 to 3 hours in hydrochloric acid ethanol and, if necessary after removing the solvent, adding acetonitrile to the obtained residue and then distilling off.