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目的:探讨心理应激对模拟高原低压低氧环境下大鼠肺损伤的影响。方法:雄性SD大鼠随机分为对照组(Con组)、低氧组(Hy组)、心理应激(2次/d)组(Ps1组)、心理应激(2次/d×2 d)组(Ps2组)、心理应激(2次/d)+低氧组(Ps1+Hy组)和心理应激(2次/d×2 d)+低氧组(Ps2+Hy组)。通过测定大鼠右肺湿/干比值、全湿肺/体重比值、右肺含水比值、血管“袖套”面积和血管“袖套”面积/血管面积的比值来评定肺损伤的程度。结果:与Con和Hy组比较,Ps2+Hy组的右肺湿/干比值、肺湿重/体重比值、血管“袖套”面积和血管“袖套”面积/血管面积比值均显著增高(P分别<0.01,0.05)。结论:心理应激可加重急性低压低氧环境导致的大鼠肺损伤。
Objective: To investigate the effect of psychological stress on lung injury induced by hypobaric hypoxia in rats. Methods: Male SD rats were randomly divided into control group (Con group), hypoxia group (Hy group), psychological stress group (Ps1 group), psychological stress (2 times / d × 2 d (Ps2 group), psychological stress (2 times / d) + hypoxia group (Ps1 + Hy group) and psychological stress (2 times / d2 d) + hypoxia group (Ps2 + Hy group). The lung injury was assessed by measuring the ratio of right / left lung wet / dry ratio, total wet lung / body weight ratio, right lung water ratio, ratio of vascular “cuff” area and vascular “cuff” area / vascular area degree. Results: Compared with the Con and Hy groups, both the wet / dry ratio of right lung, the ratio of wet weight to body weight, the area of vascular “cuff” and the area of vascular “cuff” / vascular area in Ps2 + Hy group Significantly increased (P <0.01, 0.05). Conclusion: Psychological stress can aggravate lung injury induced by acute hypoxia in rats.