从幼牛静脉血中提纯的“小牛血去蛋白提取物”(Actovegin,AC) ,主要由无机离子及小分子有机物组成。本文研究其生化性质及药效学 ,结果表明 ,AC干物质重量为 4 0 mg/ ml;AC含钾离子 1.4 8± 0 .2 6(mg/ ml) ,钠离子 10 .92± 1.4 7(mg/ ml) ,氯离子 15.92± 1.98(mg/ ml) ,多肽 1.79± 0 .2 1(mg/ ml) ,氨基酸 1.0 7± 0 .16(mg/ ml) ,葡萄糖 2 .0 1± 0 .32 (mg/ ml) ;AC具有刺激豚鼠肝匀浆线粒体呼吸的生物学活性 (呼吸活力 QO2 为 3.1μl/ mg· h,刺激指数 SI为 2 .6)。 AC药效学研究表明 ,在小白鼠全脑缺血及常压缺氧条件下 ,AC能促进血葡萄糖向脑组织转运 ,促进葡萄糖在脑组织进行有氧代谢 ,延长小白鼠存活时间 ,改善脑组织缺血、缺氧状态 ,可用于脑缺血、缺氧等疾病的治疗 Actovegin (AC), purified from veins of young veins, consists mainly of inorganic ions and small organic molecules. In this paper, its biochemical properties and pharmacodynamics were studied. The results showed that AC dry matter weight was 40 mg / ml, AC potassium ions 1.4 8 ± 0.26 (mg / ml) and sodium ions 10.92 ± 1.4 7 ( mg / ml), chloride of 15.92 ± 1.98 (mg / ml), polypeptide of 1.79 ± 0.2 (mg / ml), amino acid of 1.07 ± 0.16 (mg / ml) and glucose of 2.01 ± 0. 32 (mg / ml). AC had the biological activity of stimulating the mitochondrial respiration of guinea pig liver homogenate (the respiratory activity QO2 was 3.1 μl / mg · h and the stimulation index SI was 2.6). AC pharmacodynamic studies have shown that AC can promote the transport of blood glucose to brain tissue and promote glucose aerobic metabolism in brain tissue to prolong the survival time of mice and improve brain function under global cerebral ischemia and hypobaric hypoxia Tissue ischemia, hypoxia, can be used for cerebral ischemia, hypoxia and other diseases