论文部分内容阅读
目的研究环境暴露因素与着色性干皮病基因D多态性对慢性苯中毒发生危险性的影响。方法以152例慢性苯中毒工人为研究对象,应用单纯病例方法进行分析。结果高接触组慢性苯中毒病人XPDc.312位点Asp/Asn+Asn/Asn基因型的携带率显著高于低接触组(44.7%vs12.2%,ORadj=7.14,95%CI:1.26~40.0,P=0.03);慢性苯中毒病人XPDc.751位点Lys/Gln基因型的携带率在吸烟*低接触组高于非吸烟*低接触组(60%vs12.8%,P<0.05),但在调整性别、工龄后差异无统计学意义。结论 XPDc.312位点的基因多态与高强度苯接触存在交互作用,影响到慢性苯中毒发生的危险性。
Objective To study the influence of environmental exposure factors and genetic polymorphism of dry skin disease gene D on the risk of chronic benzene poisoning. Methods A total of 152 cases of chronic benzene poisoning workers were selected as research objects and analyzed by simple case method. Results The carrying rate of Asp / Asn + Asn / Asn genotype at XPDc.312 site in high benzene exposure group was significantly higher than that in low exposure group (44.7% vs12.2%, ORadj = 7.14, 95% CI: 1.26-40.0 , P = 0.03). The prevalence of Lys / Gln genotype at XPDc.751 in patients with chronic benzene poisoning was significantly higher in smoking-low-contact group than in non-smoking low-contact group (60% vs12.8%, P < However, after adjusting for gender, there was no significant difference after working age. Conclusion There is interaction between XPDc.312 gene polymorphism and high-intensity benzene exposure, which affects the risk of chronic benzene poisoning.