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本文总结了1970～1981年期间101例小儿急淋白血病的治疗工作。着重对化疗方法的改进、提高缓解(CR)率、延长持续完全缓解(CCR)时间及长期生存百分率诸方面进行了回顾。作者们指出,自从采用联合化疗以来CR率有了显著提高;此后又按不同危险程度选择相应方案,在最近5年中44例病孩的CR率达100%。用短程的L-ASP作巩固治疗远期疗效较好。联合化疗全程治疗组中CNSL预防用~(60)Co头颅照射或IDMTX治疗共27例,CR持续时间>4年的CCR百分率达62.9%,其中前组14例4年生存百分率为43.6%,后组13例为76.9%。坚持规则的、长期的维持治疗及定期强化治疗,对提高长期CCR率亦很重要。此外,本文还对复发的早期诊断、治疗及其预后作了讨论。
This article summarizes the treatment of 101 cases of acute leukemia in children from 1970 to 1981. A review of improvements in chemotherapeutic approaches, improvement of response (CR) rates, prolonged duration of CCR and long-term survival was reviewed. The authors note that since the introduction of combination chemotherapy, CR rates have risen significantly; thereafter, programs have been selected for varying degrees of risk, with 44% of the patients having CR rates of 100% over the last 5 years. With short-term L-ASP for the consolidation of long-term treatment is better. A total of 27 cases of CNSL prophylaxis with ~ (60) Co cranial irradiation or IDMTX were treated with combination chemotherapy. The CCR percentage of patients with CR duration> 4 years was 62.9%, of which, the 14-year survival rate of 14 cases in the former group was 43.6% Group 13 cases were 76.9%. Adhere to the rules, long-term maintenance treatment and regular intensive treatment, to improve long-term CCR rate is also important. In addition, this article also discusses the early diagnosis and treatment of relapse and its prognosis.