药物吸收速率常数Ka,是药动学的一项重要参数。精确估算Ka,有助于推算药物的生物利用度和了解体内过程。本文就Ka的各种计算方法作一综述。模型依赖性方法药动学理论的建立,有助于测定某种剂型中药物被吸收程度或相对程度,但并不要求测定药物吸收速率。结果分析,通常依赖于药动学模型。合符一级动力学药物体内过程,一般用一室或二室模型进行描述。 (一)一室模型一室模型简单地把人体描述为一个动力学上均匀单元,假设给药后 Drug absorption rate constant Ka, is an important parameter of pharmacokinetics. Accurate Ka estimation helps to predict the bioavailability of drugs and to understand the processes in the body. This article reviews various calculation methods of Ka. Model-dependent methods The establishment of a pharmacokinetic theory helps to determine the extent or relative extent of drug absorption in a given dosage form, but does not require determination of drug absorption rates. The result analysis usually depends on the pharmacokinetic model. Consistent with a kinetic drug in vivo process, the general description of the one-compartment or two-compartment model. (A) One-Room Model One-compartment model simply describes the human body as a kinetically uniform unit, assuming that after administration