通常认为米托蒽醌是非糜烂性毒剂。实验动物皮内给药并不引起典型的外渗伤害或坏死，对人类静脉注射也未见外渗或坏死。然而，仍有米托蒽醌外渗造成局部反应和组织坏死的报道。现报道一例由米托蒽醌引起的组织损伤和坏死的重度并发症。患者为66岁的老年妇女，单用米托蒽醌19毫? Mitoxantrone is generally considered a non-erosive agent. Intranasal administration of experimental animals did not cause typical extravasation injury or necrosis, and no extravasation or necrosis to human intravenous injection. However, there are still reports of mitoxantrone extravasation that cause local reactions and tissue necrosis. A severe complication of tissue damage and necrosis caused by mitoxantrone has been reported. The patient is a 66 year old woman with mitoxantrone 19 milligrams alone