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目的 :观察FOLFOX(奥沙利铂、氟尿嘧啶和甲酰四氢叶酸钙 )方案在晚期复治的结直肠癌应用中的主要毒副反应和初步疗效。方法 :回顾性分析本院在 1999年 8月至 2 0 0 1年 10月收治的应用FOLFOX方案治疗的 34例晚期复治的结直肠癌患者的临床资料。结果 :本组患者主要毒副反应表现为 :外周感觉神经毒性 76 5 % ,均为Ⅰ～Ⅱ度 ;其次是骨髓抑制、恶心、呕吐、腹泻等。总有效率 2 6 5 % (9/ 34) ,其中完全缓解和部分缓解分别为 1例 (2 9% )和 8例 (2 3 5 % )。中位生存期 10个月 ,1年生存率 36 2 %。结论 :FOLFOX方案治疗晚期复治的结直肠癌的耐受性较好 ,疗效较满意 ,有临床应用价值
Objective: To observe the main toxicities and side effects of FOLFOX (oxaliplatin, fluorouracil and leucovorin) regimen in the treatment of advanced rectal cancer. Methods: The clinical data of 34 patients with advanced rectal cancer treated with FOLFOX regimen in our hospital from August 1999 to October 2001 were retrospectively analyzed. Results: The main side effects of this group were peripheral sensory neurotoxicity of 76 5%, all of which were grade Ⅰ ~ Ⅱ, followed by myelosuppression, nausea, vomiting and diarrhea. The total effective rate was 26.5% (9/34). The complete and partial remission rates were 1 (29%) and 8 (23.5%) respectively. The median survival time was 10 months, and the 1-year survival rate was 36 2%. Conclusion: FOLFOX regimen is more tolerant to advanced retreatment of colorectal cancer, with satisfactory efficacy and clinical value