目前虽已认识到造血诱导微环境的重要性,但其性质仍待阐明。Friedenstein等将豚鼠骨髓细胞长期培养物中获得的成纤维细胞移种于同系宿主的肾包膜下时,能维持造血细胞的生长。Dexter等报告的长期骨髓培养系统,其骨髓贴壁单层细胞可支持造血干细胞增殖数月。虽然构成贴壁单层的有许多类细胞如成纤维细胞、巨噬细胞、上皮细胞和脂肪细胞等,但 Although the importance of hematopoietic microenvironment has been recognized, its nature remains to be elucidated. Friedenstein, et al., Maintained hematopoietic cell growth by transplanting fibroblasts obtained from long-term cultures of guinea pig bone marrow cells under the renal capsule of a homologous host. Dexter et al reported long-term bone marrow culture system, its bone marrow adherent monolayer cells can support the proliferation of hematopoietic stem cells for several months. Although there are many types of cells that form an adherent monolayer, such as fibroblasts, macrophages, epithelial cells, and adipocytes,