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氟哌啶是一种具有较好“协同作用”的镇静药,我们曾将氟哌啶中的对氟苯甲酰丙基接到巴比吐酸类的结构上,合成了一类新的化合物。本论文是继上述工作之后,将对氟苯甲酰丙基接到吡唑酮结构的五员环上,又得到了两个新化合物,其合成方法:将2-对氟苯基-2-丙基-1,3-二噁戊烷接到丙二酸二乙酯上,然后在乙醇钠-乙醇作用下,分别与氧化偶氮苯和苯肼反应,得到的两个中间体再分别经适当的条件,进行酸性水解,即得到两个新化合物。经红外光谱、核磁共振光谱和质谱鉴定,证明这两个新化合物结构与我们预先给定的结构是一样的。
Droperidol is a good “synergistic” sedative drug, we have fluoropyrobenzofuran propyl group to barbituric acid structure, the synthesis of a new class of compounds . After the above work, the fluorobenzoylpropyl group was connected to the five-membered ring of pyrazolone structure, and two new compounds were obtained. The synthesis method was as follows: 2-p-fluorophenyl-2- Propyl-1,3-dioxolane is connected to diethyl malonate, and then reacted with azoxybenzene and phenylhydrazine respectively under the action of sodium ethoxide-ethanol to obtain two intermediates, Appropriate conditions, acidic hydrolysis, that is, two new compounds. The results of FTIR, NMR and mass spectrometry show that these two novel compounds have the same structure as our predecessor.