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目的研究血管内皮细胞生长因子和超敏C-反应蛋白在冠心病患者血清中的变化及其临床意义。方法将76例冠心病患者分为稳定型心绞痛组(1组)、不稳定型心绞痛组(2组)、急性心肌梗死组(3组)和陈旧性心肌梗死组(4组),每组19例,同时设19例健康对照组。应用酶联免疫吸附法分别检测血清血管内皮细胞生长因子和超敏C-反应蛋白水平。结果冠心病患者血清血管内皮细胞生长因子和超敏C-反应蛋白水平升高具有正相关性,均高于对照组(P<0.05)。血管内皮细胞生长因子水平各组之间差别均有统计学意义(P<0.05);超敏C-反应蛋白水平除1组与4组之间差别无统计学意义外,其他各组之间比较差别均有统计学意义(P<0.05)。结论血管内皮细胞生长因子和超敏C-反应蛋白水平可以反映了冠心病患者的病情变化,二者联合检测对预测冠心病的病变程度、判断预后有一定价值。
Objective To study the changes of serum vascular endothelial growth factor and high sensitivity C-reactive protein in patients with coronary heart disease and its clinical significance. Methods 76 patients with coronary heart disease were divided into stable angina group (group 1), unstable angina group (group 2), acute myocardial infarction group (group 3) and old myocardial infarction group (group 4) Cases, while setting 19 cases of healthy control group. Serum levels of vascular endothelial growth factor and high sensitivity C-reactive protein were detected by enzyme-linked immunosorbent assay. Results There was a positive correlation between serum vascular endothelial growth factor and hypersensitive C - reactive protein in patients with coronary heart disease, which were higher than those in the control group (P <0.05). Vascular endothelial growth factor levels in each group differences were statistically significant (P <0.05); high-sensitivity C-reactive protein levels in addition to 1 and 4 groups, the difference was not statistically significant, the other groups were compared The differences were statistically significant (P <0.05). Conclusion Vascular endothelial growth factor and high-sensitivity C-reactive protein level can reflect the changes of patients with coronary heart disease. The combined detection of the two methods has certain value in predicting the degree of coronary artery disease and prognosis.