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目的探讨胃蛋白酶原Ⅰ(PGⅠ)和胃蛋白酶原Ⅱ(PGⅡ)在慢性胃炎筛查中的作用。方法选择浅表性胃炎、萎缩性胃炎和体检人群,分别检测PGⅠ、PGⅡ和幽门螺旋杆菌(HP),并计算PGⅠ/PGⅡ比值(PGR);对浅表性胃炎患者根据HP感染分组,鉴别PGⅠ和PGⅡ与HP感染的关系;观察PGⅠ、PGⅡ和PGR对慢性胃炎的筛查作用。结果浅表性胃炎、萎缩性胃炎、残胃胃炎患者的血清PGⅠ和PGⅡ水平均高于对照组,而3组的PGⅠ/PGⅡ比值(PGR)均低于对照组,差异有统计学意义(P<0.05)。PGR在幽门螺旋杆菌阳性组低于阴性组,差异有统计学意义(P<0.05);PGR在活动性胃炎组显著低于非活动性胃炎组,差异有统计学意义(P<0.05);HP感染(阳性)与活动性胃炎呈显著正相关(r=0.719,P<0.01)。PGⅠ、PGⅡ和PGR联合检测萎缩性胃炎患者的阳性率为62.3%。结论慢性胃炎患者血清PGⅠ和PGⅡ显著高于正常人群,而PGR显著低于正常人群,将来可能用于慢性胃炎的筛查或辅助诊断。
Objective To investigate the role of pepsinogen Ⅰ (PGⅠ) and pepsinogen Ⅱ (PGⅡ) in screening of chronic gastritis. Methods Superficial gastritis, atrophic gastritis and physical examination group were selected to detect PGⅠ, PGⅡ and Helicobacter pylori (HP), and PGⅠ / PGⅡ ratio (PGR) were calculated. According to HP infection group, PGⅠ And the relationship between PGⅡ and HP infection. To observe the screening effect of PGⅠ, PGⅡ and PGR on chronic gastritis. Results The levels of serum PGⅠ and PGⅡ in patients with superficial gastritis, atrophic gastritis and gastritis were significantly higher than those in the control group, while the PGⅠ / PGⅡ ratio (PGR) in the three groups were significantly lower than those in the control group (P <0.05). PGR was lower in Helicobacter pylori positive group than in negative group (P <0.05); PGR in active gastritis group was significantly lower than that in inactive gastritis group, the difference was statistically significant (P <0.05); HP Infection (positive) was significantly and positively correlated with active gastritis (r = 0.719, P <0.01). PG Ⅰ, PG Ⅱ and PGR combined detection of atrophic gastritis in patients with a positive rate of 62.3%. Conclusion Serum PGⅠ and PGⅡ in patients with chronic gastritis were significantly higher than those in normal people, while PGR was significantly lower than that in normal people and might be used for screening or auxiliary diagnosis of chronic gastritis in the future.