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本文测定了不同病期单纯性肾病(INS)的外周血T细胞亚群(CD_4~+/CD_~+)和ConA诱导的T抑制(Ts)细胞活性改变。并根据西咪替丁的免疫调节作用对6例初发的INS进行2周的试验治疗.结果量示,INS活动期存在CD_4~+/CD_~+降低Ts细胞活性增强.西咪替丁能纠正上述异常,但不能改善INS蛋白尿程度,推测T细胞免疫紊乱可能不是INS发病的始动因素.
In this study, we measured the changes of T cell subsets (CD_4 ~ + / CD_ ~ +) and Con A-induced T-suppressor (Ts) activity in patients with simple nephropathy (INS) According to the immunomodulatory effect of cimetidine, six newly-released INS were treated with two weeks of treatment, and the results showed that the increase of CD 4 + CD_ + To correct the above abnormalities, but can not improve the degree of INS proteinuria, suggesting that T-cell immune disorders may not be the initiating factor in the pathogenesis of INS.