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目的:通过检测愈消通脉散对糖尿病大鼠血浆和脑组织内皮素、降钙素基因相关肽水平的影响,探讨上述物质在糖尿病性脑病中的作用机理及愈消通脉散对其的调控作用。方法:采用放射免疫法检测糖尿病大鼠血浆和脑组织内皮素(ET)和降钙素基因相关肽(CGRP)水平的变化。结果:模型组大鼠血浆和脑组织内皮素-1水平与正常对照组比较显著升高,降钙素基因相关肽水平与正常组比较显著降低;中药组大鼠内皮素、降钙素基因相关肽水平与对照组比较均无显著性差异。结论:愈消通脉散防治糖尿病性脑病的机理与其调节血浆和脑组织的内皮素-1和降钙素基因相关肽水平有关。
OBJECTIVE: To investigate the effect of Yuetongtongmai on the levels of ET and CGRP in the plasma and brain of diabetic rats and to explore the mechanism of the above mentioned substances in diabetic encephalopathy Regulation. Methods: The levels of endothelin (ET) and calcitonin gene related peptide (CGRP) in plasma and brain of diabetic rats were detected by radioimmunoassay. Results: The level of endothelin-1 in plasma and brain of model group was significantly higher than that of normal control group, and the level of calcitonin gene-related peptide was significantly lower than that of normal group. The levels of endothelin and calcitonin Peptide levels compared with the control group no significant difference. Conclusion: The mechanism of Yuetongtong Powder in preventing and treating diabetic encephalopathy is related to regulating the levels of endothelin - 1 and calcitonin gene - related peptide in plasma and brain tissue.