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目的：探讨无环鸟苷（ＡＣＶ）对人白血病细胞的抗增殖和诱导分化作用。方法：将无环鸟苷加入Ｋ５６２细胞培养４ｄ，测定其活细胞数目、联苯胺染色阳性率，光镜观察形态、组织化学染色。结果：在ＡＣＶ的作用下，Ｋ５６２细胞的增殖受抑，生长分数降低，并且向具有合成血红蛋白能力的细胞分化。结论：ＡＣＶ对Ｋ５６２细胞具有抑制增殖和诱导分化作用，该结果可为慢性粒细胞白血病的治疗探索新的途径。
Objective: To investigate the effect of acyclovir (ACV) on anti-proliferation and differentiation of human leukemia cells. METHODS: Acyclovir was added to K562 cells for 4 days. The number of viable cells and the positive rate of benzidine staining were observed. The morphology and histochemical staining were observed under light microscope. RESULTS: Under the action of ACV, the proliferation of K562 cells was inhibited, the growth fraction was decreased, and cells were differentiated to have the ability to synthesize hemoglobin. Conclusion: ACV can inhibit the proliferation and induce the differentiation of K562 cells, which may be a new approach for the treatment of chronic myelogenous leukemia.