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目的：本实验选用２４月龄Ｗｉｓｔａｒ大鼠进行阿霉素处理，观察其气血变化规律，以期建立符合中医气虚血瘀辨证的慢性伤口模型。方法：采用随机法将大鼠分为生理盐水组（２３只）和阿霉素组（２４只），分别以生理盐水和８ｍｇ／ｋｇ阿霉素进行处理，背部皮肤全厚皮切除。结果：阿霉素处理的老年大鼠一般状况表现为倦怠、腹泻，体重减轻，白细胞下降，符合气虚的辨证规律。同时大鼠血浆ＴＸＢ２从实验前３５４１０±１６０７５ｐｇ／ｍｌ在处理后第３ｄ和第７ｄ分别升至６１６±１７５３３ｐｇ／ｍｌ（ｐ＜００５）和６９７７６±５５６６３ｐｇ／ｍｌ（Ｐ＜００５）；而血浆６－酮－ＰＧＦ１α则由实验前的７８３７±２６８１ｐｇ／ｍｌ分别降至６０１２±８２７ｐｇ／ｍｌ和６４１９±３５２２ｐｇ／ｍｌ，分别Ｐ＜００５，Ｐ＜００５；ＴＸＢ２／６－酮－ＰＧＦ１α的比值变化更明显，阿霉素处理第３ｄ和７ｄ分别升高至１０６９±５９８和８４９±４１８，与同期生理盐水对照组４１４±１８７，３８０±１５５相比，分别Ｐ＜００５，Ｐ＜００５，结果符合中医的血瘀证指标；同时阿霉素处理大鼠的伤口愈合时间也由对照组的１７１８±１７２?
Objective: In this study, 24-month-old Wistar rats were selected for doxorubicin treatment, and their blood and blood changes were observed in order to establish a chronic wound model that accords with TCM syndrome differentiation and blood stasis syndrome. Methods: The rats were randomly divided into saline group (n = 23) and doxorubicin group (n = 24). Rats were treated with normal saline and 8 mg / kg doxorubicin, respectively. Results: The general condition of adriamycin-treated senile rats manifested as burnout, diarrhea, weight loss, leukopenia, in line with syndrome differentiation and deficiency syndrome. At the same time, the TXB2 level in rat plasma increased from 35410 ± 16075pg / ml before the experiment to 616 ± 17533pg / ml (p <005) and 69776 ± 55663pg / Ml (P <005), while the plasma 6-keto-PGF1α decreased from 7837 ± 2681pg / ml to 6012 ± 827pg / ml and 6419 ± 35 respectively P <005, P <005, respectively. The ratio of TXB2 / 6-keto-PGF1α changed more obviously. The levels of doxorubicin increased to 1069 ± 598 849 ± 418, compared with 414 ± 187,380 ± 155 in the same period of saline control group, P <005, P <005, respectively. The results were in line with the blood of TCM Stasis index; at the same time doxorubicin treatment of wound healing in rats by the control group 17.18 ± 1.7 ?