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镉极易在人体内蓄积且很难靠自身作用排出体外,对人体危害较大。文章采用大鼠镉染毒试验,观察中药冠心康对镉染毒大鼠血管舒缩因子、黏附因子和主动脉病理及黏附因子免疫组化结果的影响,探索中药防治镉染毒致动脉硬化的可能和机理。结果:大鼠中毒后血清NO水平明显降低,ICAM-1水平明显升高(P<0.05),HE染色见动脉硬化改变,免疫组化结果见各层均有较多ICAM-1阳性表达,主要存在于粥样斑块区;冠心康低、中、高剂量条件下,NO水平均明显高于染毒组(P<0.05),ICAM-1水平较染毒组均明显降低(P<0.05),HE染色内膜较完整平坦,主动脉内膜及平滑肌层均可见少量ICAM-1阳性表达信号,但信号强度明显弱于染毒组,且平滑肌细胞形态及排列明显优于对照对照组,尤以冠心康中剂量组改善明显。提示冠心康对镉染毒大鼠动脉硬化具有保护作用。
Cadmium easily accumulate in the body and difficult to expel the body by its own role, greater harm to the human body. In this study, the rat cadmium toxicity test was used to observe the effects of Guanxinkang on the vasoconstriction factor, adhesion factor and pathological changes of aortic and the immunohistochemical results of adhesion molecules in cadmium-exposed rats. To explore the effects of traditional Chinese medicine on cadmium-induced arteriosclerosis The possibility and mechanism. Results: After the poisoning, the level of serum NO was significantly decreased and the level of ICAM-1 was significantly increased (P <0.05). The changes of atherosclerosis were observed by HE staining. The expression of ICAM-1 in each layer was higher than that in other groups (P <0.05), while the level of ICAM-1 in ICH-1 was significantly lower than that in the control group (P <0.05) ), The HE staining of the intima was more flat and flat, a small amount of ICAM-1 positive expression signal was seen in the aortic intima and smooth muscle layer, but the signal intensity was weaker than that in the infected group. The morphology and arrangement of smooth muscle cells were significantly better than the control group, Coronary heart especially in the dose group improved significantly. Prompted Guanxinkang cadmium poisoning in rats with atherosclerosis protective effect.