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目的 :探讨卵巢癌多药耐药基因产物P_糖蛋白 (P_gp)的表达与上皮性卵巢癌患者预后的关系。方法 :用免疫组织化学方法 (SP法 )对用福尔马林固定、石蜡包埋的 30例正常卵巢组织及 74例卵巢癌组织进行了P_gp检测。结果 :30例正常卵巢组织中 ,P_gp无 1例阳性 ,而卵巢癌组织中P_gp阳性率为 18.9% (14/ 74)。对 6 2例卵巢癌患者随访资料进行Kaplan_meier曲线分析 ,发现P_gp阳性组的存活率显著低于阴性组 (P <0 .0 1)。结论 :P_gp的过度表达对病人的预后具有一定的判断价值。
Objective: To investigate the relationship between the expression of P_gp and the prognosis of patients with epithelial ovarian cancer. Methods: Pgp was detected by immunohistochemistry (SP method) in 30 normal ovarian tissues and 74 ovarian cancer tissues fixed with formalin and paraffin embedded. Results: None of the 30 normal ovarian tissues had positive P_gp, while the positive rate of P_gp in ovarian cancer was 18.9% (14/74). Kaplan-Meier curve analysis of 62 patients with ovarian cancer follow-up data showed that the survival rate of P_gp positive group was significantly lower than that of negative group (P <0.01). Conclusion: Overexpression of P_gp has certain value in judging the prognosis of patients.