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目的 探讨尿α1 微球蛋白 (α1 MG)、尿β2 微球蛋白 (β2 MG)和尿微量白蛋白 (Alb)的检测对评价系统性红斑狼疮 (SLE)患者早期肾损害的意义。方法 采用RIA法分别测定了SLE患者的尿α1 MG ,β2 MG和Alb ,并与健康人进行比较。结果 SLE患者的尿α1 MG ,β2 MG和Alb测定结果分别为4 7.8± 5 4.3mg L ,339.7± 2 35 μg L和 6 4.3± 75 .5mg L ,分别与健康对照组比较 ,差异均有显著性 (P <0 .0 1) ,SLE组比健康对照组显著升高。SLE患者中尿常规异常组的α1 MG ,β2 MG和Alb的测定结果为 4 6 .3± 5 5 .4mg L ,4 97.9± 2 2 5 .4 μg L和 99.9± 71.7mg L ,分别与尿常规正常组比较 ,α1 MG在两组间差异无显著性 (P >0 .0 5 ) ,而β2 MG和Alb差异显著 (P <0 .0 1) ,尿常规异常组明显高于尿常规正常组。结论 尿α1 MG ,β2 MG和Alb的测定能够反映SLE患者早期肾损害 ,且对于评价肾脏受损程度有一定意义
Objective To investigate the significance of urinary α1 microglobulin (α1 MG), urinary β2 microglobulin (β2 MG) and urinary albumin (Alb) in the assessment of early renal damage in patients with systemic lupus erythematosus (SLE). Methods Urine α1 MG, β2 MG and Alb were measured by RIA in patients with SLE and compared with healthy controls. Results The results of urinary α1 MG, β2 MG and Alb in SLE patients were 4 7.8 ± 5 4.3 mg L, 339.7 ± 2 35 μg L and 6 4.3 ± 75 .5 mg L, respectively, which were significantly different from those in healthy controls (P <0.01), the SLE group was significantly higher than the healthy control group. The results of α1 MG, β2 MG and Alb assay in patients with abnormal urinary levels of SLE were 46.3 ± 5.54 mg L, 4 97.9 ± 22.54 μg L and 99.9 ± 71.7 mg L, respectively, Compared with normal control group, α1 MG had no significant difference between the two groups (P> 0.05), while there was significant difference between β2 MG and Alb (P <0.01). Urinary abnormalities were significantly higher than normal urinary group. Conclusion The determination of urinary α1 MG, β2 MG and Alb can reflect early renal damage in patients with SLE, and has some significance for evaluating the extent of renal damage