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利用重度犬烟雾吸入伤模型,观察了血中粒细胞的动态变化,及其在烟雾吸入性肺损伤中的作用。伤后血中粒细胞很快向肺内聚集和浸润;多核粒细胞(PMN)对自体细胞的毒性效应显著增强;PMN释放的髓过氧化物酶不断增加;代表氧自由基产生的PMN化学发光显著改变;这些变化均先于肺损伤,与其损伤时相基本一致。提示肺内粒细胞聚集和浸润在吸入性肺损伤中具有重要作用,颗粒酶和氧自由基可能是粒细胞介导肺损伤的效应因素。
Severe canine smoke inhalation injury model was used to observe the dynamic changes of blood neutrophils and their role in smoke-induced lung injury. After injury, the granulocytes in the blood quickly gathered and infiltrated into the lungs; the toxic effects of the multinucleated granulocytes (PMN) on the autologous cells were significantly enhanced; the release of PMN by the PMN was continuously increased; PMN chemiluminescence represented by oxygen free radicals Significant changes; these changes are preceded by lung injury, and its injury is basically the same phase. It is suggested that granulocyte aggregation and infiltration play an important role in inhalation lung injury. Granzyme and oxygen free radicals may be the effector factors of granulocyte-mediated lung injury.