论文部分内容阅读
盐酸氟西汀是一有效的抗抑郁药，对酒精中毒、焦虑、慢性疼痛等亦有潜在的治疗作用。本文报道光学活性氟西汀以及类似物去甲氟西汀等的简便合成法。其合成关键中间体为3－苯基－3－羟基丙胺[C6H5CH（OH）CH2CH2NH2]，系自乙睛与苯甲醛经两步反应，高收率地制得其外消旋体。然后
Fluoxetine hydrochloride is a potent antidepressant and has potential therapeutic effects on alcoholism, anxiety and chronic pain. This article reports the facile synthesis of optically active fluoxetine and its analogues, such as norfluoxetine. Its key synthetic intermediates are 3-phenyl-3-hydroxypropylamine [C6H5CH (OH) CH2CH2NH2], which is prepared from the racemate of ethyl ester and benzaldehyde in two steps with high yield. then