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目的探讨苯海拉明联合盐酸氟桂利嗪及山莨菪碱治疗周围性眩晕的临床效果及安全性。方法选择沅江市人民医院2010年8月至2012年8月收治的周围性眩晕患者121例,随机分为两组,所有患者入院后均给予常规治疗,在此基础上对照组58例患者给予盐酸氟桂利嗪胶囊口服,观察组63例患者给予盐酸氟桂利嗪胶囊口服,静脉推注山莨菪碱,苯海拉明肌肉注射。并对两组患者的临床疗效及安全性进行评价。结果治疗后观察组显效24例,有效34例,无效5例,总有效率92.1%,显著高于对照组的79.3%(P<0.05),且两组均未见严重的不良反应。结论苯海拉明联合盐酸氟桂利嗪、山莨菪碱能够快速改善患者眩晕症状,有效率高,安全,值得临床推广。
Objective To investigate the clinical effect and safety of diphenhydramine combined with flunarizine hydrochloride and anisodamine in treatment of peripheral vertigo. Methods 121 patients with peripheral vertigo who were treated in Yuanjiang People’s Hospital from August 2010 to August 2012 were randomly divided into two groups. All patients were given routine treatment after admission. On the basis of this, 58 patients in control group were given hydrochloric acid Flunarizine capsules orally, the observation group of 63 patients given flunarizine hydrochloride capsules oral intravenous injection of anisodamine, diphenhydramine intramuscular injection. The clinical efficacy and safety of the two groups were evaluated. Results After treatment, the observation group was significantly improved in 24 cases, effective in 34 cases, ineffective in 5 cases, the total effective rate was 92.1%, significantly higher than 79.3% of the control group (P <0.05), and no serious adverse reactions in both groups. Conclusion Diphenhydramine combined with flunarizine hydrochloride and anisodamine can rapidly improve the symptoms of vertigo in patients with high efficiency, safety and worthy of clinical promotion.