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应用大白鼠连续ig给药4周,对欧达胃克的长期用药毒性进行观察,结果,低剂量组(350mg·kg~(-1);相当于临床量的2.3倍)和中剂量组(700mg·kg~(-1),4.5倍量)与对照组比较各项指标无显著差异。高剂量组(1232.0mg·kg~(-1),8倍量)用药2周活动逐渐减少,饮食量下降,体重减轻。用药3周高剂量组有30％大鼠站立行走不便,出现肌张力障碍。测大鼠坐骨神经复合动作电位,表现抑制现象,兴奋阈降低。高剂量组BUN有可逆性升高。实验结束时有3只大鼠死于呼吸抑制(死亡率未超过20％)。
The long-term toxicity of Ondanweike was observed in rats using ig administration for 4 weeks. As a result, the low dose group (350 mg · kg -1; equivalent to 2.3 times the clinical dose) and the middle dose group 700mg · kg ~ (-1), 4.5 times the amount of) compared with the control group showed no significant difference. High-dose group (1232.0mg · kg -1, 8 times the amount) medication 2 weeks activity decreased, decreased diet, weight loss. 30% rats in the high-dose 3-week medication group stood up and walked inconveniently with dystonia. Measuring rat sciatic nerve compound action potential, the phenomenon of inhibition, excitement threshold decreased. High-dose group BUN reversible increase. Three rats died of respiratory depression at the end of the experiment (mortality did not exceed 20%).