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目的 探讨米索前列醇 (米索 )用于足月妊娠引产的安全性 ,以及减少诱导临产时间、降低其用量的性能。方法 选择 90例有引产指征的足月妊娠孕妇随机分为 3组。A组 :催产素引产组 (按催产素引产常规 )。B组 :第 1天用催产素引产 ,若未成功 ,第 2天改用米索引产。C组 :米索引产。米索开始剂量 2 5～ 50μg,宫颈管内放药 ,隔 3～ 4 h口服 2 5～ 50μg,最大剂量 2 0 0μg。结果 B,C两组比较差异无显著性 ( P>0 .0 5) ,A与 B,C两组比较差异均有显著性 ( P<0 .0 5) ,但 B组较 C组诱导临产时间明显缩短 ( P<0 .0 1) ,用药量 B组较 C组减少 ,产程时间 B,C组较 A组缩短。结论 催产素引产未成功改米索引产成功率高 ,用药量少 ,临产时间短 ,有利于计划分娩。
Objective To investigate the safety of misoprostol (misoprostol) in induction of labor during term pregnancy, and to reduce the induction of labor and reduce its dosage. Methods Ninety pregnant women of full-term pregnancy who had indications for induction of labor were randomly divided into three groups. Group A: oxytocin induction group (according to oxytocin induction). Group B: The first day with oxytocin induction, if not successful, the second day to switch to misoprostol. Group C: Misoprostol. The dose of misoprost was 25 ~ 50μg. The cervix was treated by oral administration of 25 ~ 50μg every 3 ~ 4 hours and the maximum dose was 200μg. Results There was no significant difference between group B and group C (P> 0.05), but there was significant difference between group A and group B and group C (P <0.05), but group B was more induced than group C The time was significantly shorter (P <0.01), the dosage of B group decreased compared with C group, labor duration B, C group shorter than A group. Conclusion Oxytocin induction of labor failed to change the success rate of misoprostol induction, less medication, short duration of labor, is conducive to the planned delivery.