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目的观察癫患者长期服用丙戊酸钠后记忆功能的改变及其影响因素。方法用《临床记忆量表》对研究对象进行长期随访评估。结果服用丙戊酸钠的患者2a内记忆商数显著性下降,影响因素有受教育年限、入组后月癫性发作次数、入组后日平均药物剂量。结论受教育年限、入组后月癫性发作次数、入组后日平均药物剂量对服用丙戊酸钠的患者的记忆功能具有显著性影响,这些因素的影响对临床和基础研究具有一定意义。
Objective To observe the change of memory function and its influencing factors after long-term taking sodium valproate in patients with epilepsy. Methods Long-term follow-up assessment of the study subjects was conducted using the Clinical Memory Scale. Results Patients taking sodium valproate had a significant decrease in the quotient of memory after 2a, and the influencing factors were the number of years of education, the number of epileptic seizures and the average daily dose of drugs after enrollment. Conclusions The number of years of education, the number of epileptic seizures and the mean daily dose of drugs after enrollment have significant effects on the memory function of patients taking sodium valproate. The influence of these factors has some significance on clinical and basic research .