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鱼肝细胞色素P-450酶的诱导已用作监测水污染的指标。棉鼠(Sigmodon hispidus)在种系发生方面更接近于人,生活上与人很接近,在毒理学研究方面可能优于鱼。本研究的目的是,通过对野生棉鼠肝细胞色素P-450水平的评价,建立一可靠、快速和灵敏方法,用于确定环境毒物对人和动物的危害性。研究在饿克拉荷马州一25公顷污物处理场主沟及桶堆周围进行,该地大部复盖高草。另选生态学相似而无污染的地方做对照区。采用各间隔10m、8×8网格式布置以燕麦为诱饵的10.2×10.2×22.9cm铝质捕鼠器捕三天计算密度。放鼠前记体重、性别,并剪趾作标记。第三天捕到的鼠送试验室单个装笼,禁食
Induction of fish liver cytochrome P-450 enzyme has been used as an indicator of water contamination. The cotton germ (Sigmodon hispidus) is closer to humans in germline development and lives close to humans and may be superior to fish in toxicological research. The purpose of this study was to establish a reliable, rapid and sensitive method for assessing the hepatocyte cytochrome P-450 levels in wild cotton rats for the purpose of determining the toxicity of environmental poisons to humans and animals. The study was conducted around the main ditches and barrels at a 25-hectare waste disposal ground in the hungry state of Oklahoma, which mostly covered tall grass. Alternative ecological areas without pollution similar control areas. Density was calculated for three days using 10.2 × 10.2 × 22.9 cm aluminum mouse traps arranged in 10 × 8 × 8 grids with oats as bait. Put mice before weight, sex, and cut toe for the mark. The rats caught on the third day were sent to the laboratory for a single cage and fasted