论文部分内容阅读
目的 :探讨血管紧张素转移酶 (ACE)基因插入 /缺失 (I/D)多态性与儿童哮喘的关系。方法 :采用聚合酶链反应(PCR)方法检测 5 2例哮喘患儿 ,40例正常儿童的ACE基因型。结果 :哮喘组DD基因型频率和D等位基因频率分别为 35 %和 45 % ,而正常对照组为 13%和 31%。两组比较有显著性差异 (P <0 .0 5 ) ,携带DD基因型与非DD基因型的哮喘患儿间最大呼气流量占预计值的百分比无显著性差异 (P >0 .0 5 )。结论 :ACE基因DD基因型与哮喘的易感性有关 ,可能是哮喘的危险因素 ,而与气道阻塞程度无关。
Objective: To investigate the relationship between angiotensin transferase (ACE) gene insertion / deletion (I / D) polymorphism and childhood asthma. Methods: ACE genotypes were detected in 52 children with asthma and 40 normal children by polymerase chain reaction (PCR). Results: The frequency of DD genotypes and D allele in asthma group were 35% and 45%, respectively, compared with 13% and 31% in the normal control group. There was a significant difference between the two groups (P <0.05). There was no significant difference in the maximum expiratory flow of children with DD genotypes and non-DD genotypes (P> 0.05) ). Conclusion: The DD genotype of ACE gene is related to the susceptibility to asthma and may be a risk factor for asthma, but not to the degree of airway obstruction.