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目的制备维生素K1注射乳,并考察其在小鼠体内的分布情况。方法采用微射流仪制备维生素K1注射乳;维生素K1注射乳剂和普通注射剂从尾静脉注射至小鼠体内,采用HPLC法测定维生素K1在小鼠体内各组织的浓度。结果维生素K1注射乳粒径为(172.2±63.0)nm,注射给药后,维生素K1注射乳组的肝、脾中维生素K1的AUC值分别为注射液组的2.34和2.70倍。结论维生素K1注射乳在小鼠体内具有显著肝、脾靶向性。
Objective To prepare Vitamin K1 injection milk and investigate its distribution in mice. Methods Vitro K1 injection milk was prepared by micro-jet apparatus. Vitamin K1 injection emulsion and common injection were injected into the mice from the tail vein. The concentrations of vitamin K1 in various tissues of mice were determined by HPLC. Results The diameter of vitamin K1 injection was (172.2 ± 63.0) nm. After injection, the AUC of vitamin K1 in liver and spleen of vitamin K1 injection group were 2.34 and 2.70 times higher than that of injection group respectively. Conclusion Vitamin K1 injection has significant liver and spleen targeting in mice.