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To determine the affinity and the specificity of new opioid receptor ligands on δ or μ opioid receptors. Methods: The binding characteristics of opioid ligand [~3H] -diprenorphine was studied in cloned δ and μ opioid receptors stably expressed in Chinese hamster ovary cells in saturation binding experiments and were followed by competition binding experiments with a variety of new synthesized opioid receptor ligands. The effect of
To determine the affinity and the specificity of new opioid receptor ligands on δ or μ opioid receptors. Methods: The binding characteristics of opioid ligand [~ 3H] -diprenorphine was studied in cloned δ and μ opioid receptors stably expressed in Chinese hamster ovary cells in saturation binding experiments and were followed by competition binding experiments with a variety of new synthesized opioid receptor ligands. The effect of