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目的:观察托吡酯单药治疗小儿癫痫的临床疗效。方法:将确诊为癫痫的患儿随机分为托吡酯治疗组90例和丙戊酸治疗组66例,托吡酯治疗组采用托吡酯单药治疗,起始量为0.5mg/(kg.d),分2次口服,5d加量1次,直至加至目标剂量为5mg/(kg.d);丙戊酸治疗组采用丙戊酸钠单药治疗,起始量为10mg/(kg.d),分3次口服,5d加量1次,直至加至目标剂量为30mg/(kg.d)。比较两组在临床疗效和副作用方面的差异。结果:托吡酯治疗组总有效率为88.89%;丙戊酸治疗组总有效率为89.39%,两组在疗效上比较无显著性差异(P>0.05)。但托吡酯治疗组患儿中8例出现不良反应,占8.89%;而丙戊酸组患儿中有25例出现副作用,占37.88%,两组比较有显著性差异(P<0.05)。结论:托吡酯治疗小儿癫痫与传统药丙戊酸比较疗效相近,且无明显毒副作用。
Objective: To observe the clinical efficacy of topiramate monotherapy in children with epilepsy. Methods: 90 children diagnosed as epilepsy were randomly divided into topiramate treatment group and valproate treatment group, 66 cases, topiramate treatment group with topiramate monotherapy, the initial amount of 0.5mg / (kg.d), divided into 2 Oral administration, 5d plus 1, until the target dose was added to 5mg / (kg.d); valproate treatment group with sodium valproate monotherapy, the initial amount of 10mg / (kg.d), points 3 times orally, 5d plus 1, until the target dose is added to 30mg / (kg.d). The differences in clinical efficacy and side effects between the two groups were compared. Results: The total effective rate of topiramate treatment group was 88.89%. The total effective rate of valproic acid treatment group was 89.39%. There was no significant difference between the two groups (P> 0.05). However, 8 of the topiramate-treated children showed adverse reactions, accounting for 8.89%; 25 of them had side effects, accounting for 37.88%. There were significant differences between the two groups (P <0.05). Conclusion: Topiramate treatment of pediatric epilepsy and valproic acid traditional efficacy similar, and no significant side effects.