本文使用Billingham等人的方法建立了近交系SW1小鼠对C57BL小鼠的新生同种移植耐受的动物模型,并对其发生机理进行了初步探讨.结果表明,新生同种移植耐受的发生机理不能单纯地用“克隆缺失”学说来解释,而是由包括抑制细胞在内的外围主动抑制机制参与介导和维持.这种抑制细胞对射线不敏感却对丝裂霉素C处理相对敏感的实验结果提示,该抑制细胞可能是一“非均一”群体,对此尚须作进一步深入研究。 In this paper, we used the method of Billingham et al. to establish an animal model of neonatal allograft tolerance in inbred SW1 mice to C57BL mice, and to explore the mechanism of its occurrence. The results showed that the newborn allograft tolerant The mechanism of occurrence cannot be explained simply by the “clone deletion” hypothesis, but is mediated and maintained by the peripheral active inhibitory mechanisms including suppressor cells. This inhibitory cell is not sensitive to radiation but is relatively resistant to mitomycin C treatment. Sensitive experimental results suggest that the suppressor cell may be a “non-homogeneous” population, and further research is needed for this.