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目的了解河南省洛阳市丙型肝炎(丙肝)病毒(Hepatitis C Virus,HCV)感染的危险因素,为预防控制丙肝提供参考。方法采用病例一对照研究的方法 ,以性别和年龄作为匹配因素,按照1:2的配对原则选择研究对象,地区分层抽取14例病例和28例对照,开展相应的问卷调查和血清学检测,以确定HCV感染的危险因素。结果 logistic回归分析丙肝感染的危险因素显示,输血史、有偿采供血史、使用血制品史3个与血液感染的因素关联强度最大;与丙肝病人或携带者一起生活关联强度较大;与传统治疗造成皮肤黏膜破损和手术史中度关联,与不规范注射行为关联强度最小。城乡分层结果发现,纹身、手术史、口腔诊疗史、输血史、不规范注射和有偿采供血史在城市和农村均有统计学意义,但穿耳洞(OR值1.70)、内窥镜检查史(OR值2.73)和针灸刮痧史(OR值2.57)仅对城市有统计学意义,使用血制品史(OR值2.89)仅对农村有统计学意义。结论输血史、有偿采供血史、使用血制品史、与丙肝病人或携带者一起生活、手术史、不规范注射可能是洛阳市丙肝病例发生的危险因素。控制医源性感染是阻断丙肝传播的关键。
Objective To understand the risk factors of Hepatitis C Virus (HCV) infection in Luoyang, Henan Province, and to provide a reference for the prevention and control of hepatitis C. Methods A case-control study was conducted. Gender and age were used as matching factors. According to the principle of 1: 2 matching, 14 subjects and 28 controls were selected by region. Corresponding questionnaires and serological tests were conducted. To determine the risk factors for HCV infection. Results Logistic regression analysis of risk factors for hepatitis C infection showed that blood transfusion history, history of paid blood collection and history of blood products had the highest correlation with the factors of blood infection. The intensity of life associated with hepatitis C patients or carriers was greater than that of traditional treatment Resulting in the skin mucosa damage and the history of moderate correlation, and non-standard injection behavior associated with the minimum intensity. The results of stratification between urban and rural areas showed that the history of tattooing, surgery, oral medical history, blood transfusion, non-standard injection and paid blood collection were statistically significant in urban and rural areas, but ear piercing (OR 1.70), endoscopy The history (odds ratio 2.73) and acupuncture scraping history (odds ratio 2.57) were only statistically significant in the city. The history of blood products (odds ratio 2.89) was only statistically significant in rural areas. Conclusions Blood transfusion history, history of paid blood collection, history of blood products, living with hepatitis C patients or carriers, history of surgery and nonstandard injection may be the risk factors of hepatitis C in Luoyang. Control of iatrogenic infection is the key to blocking the spread of hepatitis C.