依赖维生素K凝血因子缺乏症分遗传性及继发性两种。遗传性极少见。继发性以肝病引起凝血因子合成障碍,继生素K吸收不良,口服抗凝剂,DIC等较多见。本文报道1例为药物引起的依赖维生素K凝血因子缺乏症,国内少见报道。 患者张某,女,41岁。1983年4月7日因受凉头晕乏力,8日卫生所按感冒处理,3次/日分别服安乃近1.0g、APC0.50g、四环素0.50g,感冒症状缓解。9日发现鼻衄,12日咯带血痰,皮肤以及四肢关节附近 Dependent on vitamin K deficiency factor sub-hereditary and secondary two. Hereditary rare. Secondary to liver disease caused by clotting factor synthesis, followed by poor absorption of antibiotics K, oral anticoagulants, DIC more common. This article reports a case of drug-dependent vitamin K deficiency factor, rarely reported in China. Zhang patients, female, 41 years old. April 7, 1983 due to dizziness, dizziness, 8, according to the cold clinics at the clinic, 3 times / day were nearly 1.0g Annapurna, APC0.50g, tetracycline 0.50g, relieve the symptoms of cold. On the 9th found epistaxis, bloody sputum on the 12th, skin and limbs near the joints