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目的观察输注不同剂量异丙酚对兔肝血流量(BF)和肝氧供需平衡的影响。方法30 只成年雄性健康家兔随机分为高剂量组(n=11,输注异丙酚1.2 mg·kg-1·min-1)、低剂量组(n=10,输注异丙酚0.4mg·kg-1·min-1)和对照组(n=9,输注等容量5%葡萄糖),静脉注射3%戊巴比妥钠麻醉后,气管插管、机械通气,开腹游离门静脉和肝动脉,行颈总动脉、门静脉、肝静脉插管。循环稳定后给药,电磁血流仪连续测定给药后0(给药前即刻)、10、20、30、40、50、60、70、80、90 min的门静脉和肝动脉BF,于给药后0、30、50、70、90 min采颈总动脉、门静脉、肝静脉血各0.5ml作血气分析,计算肝氧供(DO2)、氧耗(VO2)。结果高剂量组在给药后30-90min时肝BF较给药前即刻和对照组增加(P< 0.05或0.01),同期肝DO2、VO2也较对照组增加(P<0.05),肝DO2/VO2组间和组内比较差异无统计学意义。结论高剂量异丙酚可增加肝BF和肝DO2,同时也增加肝VO2,但尚能维持肝DO2/VO2。
Objective To observe the effects of different doses of propofol on the balance of hepatic blood flow (BF) and hepatic oxygen supply in rabbits. Methods Thirty adult male healthy rabbits were randomly divided into high dose group (n = 11, propofol 1.2 mg · kg -1 · min -1), low dose group (n = 10, propofol 0.4 After the rats were anesthetized with 3% pentobarbital sodium, the animals were intubated, mechanically ventilated, and the laparotomy portal vein was opened And the hepatic artery, common carotid artery, portal vein, hepatic vein catheterization. Circulating stability after administration, continuous determination of electromagnetic flow meter 0 (immediately before administration), 10,20,30,40,50,60,70,80,90 min portal vein and hepatic artery BF, to give Blood samples were collected from the common carotid artery, portal vein and hepatic vein at 0, 30, 50, 70, and 90 min after drug administration for blood gas analysis. DO2 and VO2 were calculated. Results Compared with the control group (P <0.05 or 0.01), the levels of liver DO2 and VO2 in the high dose group increased significantly (P <0.05 or P <0.05) There was no significant difference between VO2 groups and groups. Conclusion High-dose propofol can increase liver BF and liver DO2, but also increase liver VO2, but still maintain the liver DO2 / VO2.