Infection rate of hepatitis B virus(HBV) in our country remains high. Many patients showed combined HBV infection; the most common blood system disease is non-Hodgkin’s lymphoma(NHL)-combined HBV infection. Drugs used in treating lymphoma may induce different degrees of HBV reactivation. Such condition may lead to hepatic failure or death. Currently, scholars pay increasing attention to reactivation of HBV by rituximab and/or chemotherapy for NHL-combined HBV patients. This study summarizes research advances in this topic, with a view of providing background information for further research. Many of the patients showed combined HBV infection; the most common blood system disease is non-Hodgkin’s lymphoma (NHL) -combined HBV infection. Drugs used in treating lymphoma may induce different degrees Currently, scholars pay attention attention to reactivation of HBV by rituximab and / or chemotherapy for NHL-combined HBV patients. This study summarizes research advances in this topic, with a view of providing background information for further research.