论文部分内容阅读
本世纪中叶,所有可供临床使用的强效吸入性麻醉药至少有两项缺点,即与氧混用时易爆炸或有一定毒性。50年代末引入碳原子与氟化物结合的新一代吸入麻醉药,既不易燃又稳定,而且代谢减少,所以毒性减弱。自1956年开始大量使用氟烷之后,因摄取、消除和代谢几乎无害,所以认为比较接近理想。几年后才肯定了氟烷对呼吸和循环的抑制,伍用肾上腺素时可导致心律失常以及对肝脏可能有毒,尤其“氟烷性肝炎”的死亡率又很高。继续研究,注意力又集中
By the middle of this century, all potent inhalation anesthetics available for clinical use have at least two drawbacks: explosive or toxic when mixed with oxygen. The introduction of a new generation of inhalation anesthetics that incorporate carbon atoms and fluoride in the late 1950s is neither flammable nor stable, and its metabolism is diminished, resulting in reduced toxicity. Since the heavy use of halothane since 1956, it is considered to be relatively close to ideal because it is almost harmless because of ingestion, elimination and metabolism. A few years later, halothane has been shown to inhibit respiratory and circulatory arrest. Adrenergic drugs can lead to arrhythmias and may be toxic to the liver. In particular, “halothane” has a high mortality rate. Continue to study, attention and focus