论文部分内容阅读
目的探讨维生素K3降低肾结石模型大鼠尿草酸排泄的量效关系。方法选用80只雄性SD大鼠,体重200~250g,随机分为8组,分别为空白对照组、单纯VitK3组、单纯诱石组、诱石+4.0、3.0、2.0、0.8、0.4mg/dVitK3干预组,每组各10只。观察其24h尿草酸排泄量的变化。结果维生素K3对正常饮食大鼠无降低尿草酸作用(P>0.05),对诱石剂导致的24h尿草酸排泄量增加有明显的干预作用,干预剂量0.4mg/d时即已起效,24h尿草酸排泄量减少2.2%,随着干预剂量的增加,24h尿草酸排泄量增量逐渐减少,2mg/d时效果已相当明显,达到27.2%,其量效关系呈S型曲线,偏相关系数=-0.877(P<0.05)。结论维生素K3可有效降低诱石组大鼠24h尿草酸排泄量,并呈剂量依赖性。
Objective To investigate the dose-response relationship between vitamin K3 and urinary oxalate excretion in rats with kidney stone. Methods Eighty male Sprague-Dawley rats weighing 200-250 g were randomly divided into 8 groups: blank control group, VitK3 group, simple lure group, lure + 4.0, 3.0, 2.0, 0.8 and 0.4 mg / dVitK3 Intervention group, each group of 10. Observed 24h urine oxalic acid excretion changes. Results Vitamin K3 had no effect on reducing oxalic acid in normal diet rats (P> 0.05), and it had a significant effect on urinary oxalic acid excretion excreted by 24 h urinary excretion. When intervention dose was 0.4 mg / d, The urinary oxalic acid excretion decreased by 2.2%. With the increase of intervention dose, the excretion of urinary oxalate acid decreased gradually at 24 hours, and the effect was obvious at 2mg / d, reaching 27.2%. The dose-response relationship was S-curve, partial correlation coefficient = -0.877 (P <0.05). Conclusion Vitamin K3 can effectively reduce 24h urine oxalic acid excretion in a dose-dependent manner.