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用Y-型迷路箱测定福定碱对小鼠空间辨认学习和记忆过程的影响。福定碱5～100μg/kg于训练前30分钟、训练后立即及训练后24小时腹腔注射,明显减少达标所需的训练次数,增加主动回避反应。其促进作用呈剂量依赖关系。口腔给药也有类似的效果。电脑休克对小鼠学习记忆能力有损害作用,而福定碱40μg/kg有明显的保护小鼠免受损害的作用,使记忆的获得、巩固及再现三个过程基本上恢复到正常动物的水平。
Effect of Furosemide on Spatial Identification Learning and Memory of Mice by Y-shaped Mast. Fuding base 5 ~ 100μg / kg 30 minutes before training, immediately after training and training 24 hours after intraperitoneal injection, significantly reduce the number of training required to meet the standard to increase the active avoidance response. The promotion effect was dose-dependent. Oral administration also has similar effects. Computer shock had a detrimental effect on the ability of learning and memory in mice, while 40μg / kg of furadine had a significant protective effect on mice, which basically restored the recovery, consolidation and reproduction of memory to normal animals .