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目的:分析和研究硫酸镁联合硝苯地平治疗子痫前期重度临床效果。方法:我们选取2011年8月-2013年10月子痫前期重度患者84例,将其随机分为观察组42例与对照组42例。对照组患者给予硫酸镁注射液治疗;观察组患者在对照组治疗基础上加用硝苯地平缓释片治疗。将两组患者血压值控制情况及围产儿结局进行对比。结果:观察组患者治疗后平均收缩压、24小时尿蛋白检测值均明显低于对照组;观察组患者终止妊娠时间明显长于对照组(P<0.05),具有统计学意义。观察组围产儿结局明显优于对照组(P<0.05),具有统计学意义。结论:将硫酸镁与硝苯地平联合应用于子痫前期重度患者治疗中,能够有效控制患者血压水平值,延长孕期,对改善围产儿结局有重要作用。
Objective: To analyze and study the clinical effect of magnesium sulfate combined with nifedipine in the treatment of severe preeclampsia. Methods: We selected 84 patients with severe preeclampsia from August 2011 to October 2013, and randomly divided them into observation group (42 cases) and control group (42 cases). Patients in the control group were treated with magnesium sulfate injection. Patients in the observation group were treated with nifedipine sustained-release tablets on the basis of the control group. The two groups of patients with blood pressure control and perinatal outcomes were compared. Results: The average systolic blood pressure and the 24-hour urinary protein in the observation group were significantly lower than those in the control group. The termination of pregnancy in the observation group was significantly longer than that in the control group (P <0.05). The outcome of perinatal observation group was significantly better than the control group (P <0.05), with statistical significance. Conclusion: The combination of magnesium sulfate and nifedipine in the treatment of severe preeclampsia patients can effectively control the level of blood pressure in patients, prolong the pregnancy and plays an important role in improving perinatal outcome.