研究了茜草(Rubia cordifolia)水-乙醇提取物对四氯化碳和对乙酰氨基酚所致肝毒性的作用。①提取物对对乙酰氨基酚引起的致死率的影响:口服对乙酰氨基酚1g/kg可使小鼠100%死亡,而预先服用提取物1g/kg,小鼠死亡率为30%,②提取物对对乙酰氨基酚所致肝毒性的作用:大鼠分成三组,第一组,作空白对照,口服生理盐水(10ml/kg)和赋形剂(1%甲基纤维素13ml/kg);第二组分四次口服生理盐水,每次间隔12小时,最后一次给盐水后1小时口服对乙酰氨基酚(640mg/kg);第三组,将生理盐水换成茜草 The effects of water-ethanol extracts of Rubia cordifolia on hepatotoxicity induced by carbon tetrachloride and acetaminophen were studied. 1 Effects of extracts on acetaminophen-induced lethality: oral administration of acetaminophen 1 g/kg caused 100% mortality in mice, whereas pre-administered extract 1 g/kg, mouse mortality rate 30%, 2 extraction Effect of paracetamol on hepatotoxicity induced by acetaminophen: rats were divided into three groups, the first group, as a blank control, oral normal saline (10 ml/kg) and vehicle (1% methylcellulose 13 ml/kg) The second component was administered orally with normal saline four times at intervals of 12 hours, and oral acetaminophen (640 mg/kg) was given 1 hour after the last administration of saline; the third group was replaced with saline