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丙型肝炎是一种由丙型肝炎病毒引起的传染病。治疗丙型肝炎感染主要应用干扰素或干扰素加利巴韦林。干扰素治疗丙型肝炎可引起抑郁症,通常发生在干扰素治疗开始后1～8周,其发生率为17%～82%。引起抑郁症的因素涉及患者的遗传、治疗前的神经精神状态、丙型肝炎本身和干扰素的剂量、疗程、给药途径及制剂品种。干扰素诱发抑郁症的机制现认为:5-HT水平降低、下丘脑-垂体-肾上腺素皮质轴激活、炎性细胞因子活化以及细胞间粘附分子-1增多、氧化亚氮水平升高、二肽基肽酶水平降低。抑郁症的防治包括治疗前对患者状态的评估,以及出现抑郁症后对抗抑郁药的正确选用。
Hepatitis C is an infectious disease caused by the hepatitis C virus. The treatment of hepatitis C infection mainly uses interferon or interferon plus ribavirin. Interferon treatment of hepatitis C can cause depression, usually occurs 1 to 8 weeks after the start of interferon therapy, the incidence of 17% to 82%. Depression caused by factors related to the patient’s genetic, pre-treatment neuropsychiatric state, hepatitis C itself and the dose of interferon, treatment, route of administration and preparation varieties. Interferon-induced depression is now considered the mechanism: 5-HT levels, hypothalamic-pituitary-adrenal cortex axis activation, activation of inflammatory cytokines and intercellular adhesion molecule-1 increased nitric oxide levels, Peptide peptidase levels are reduced. Prevention and treatment of depression include the assessment of the patient’s condition before treatment and the correct selection of antidepressants after depression.