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系统性硬化病是一种临床上以局限性或弥漫性皮肤增厚和纤维化为特征的结缔组织病,可累及心、肺、肾、消化道等多个系统。硬皮病肾危象(scleroderma renal crisis,SRC)是系统性硬化病内脏损害中最危急的并发症之一,多数预后不良。现报告1例SRC,并进行文献复习。1临床资料患者女性,58岁,因反复雷诺现象伴皮肤发硬9个月,头痛、恶心、纳差3 d入院。9个月前上呼吸道感染后出现双手遇冷发白、麻木,指端及面部皮肤逐渐变硬。1个月前在外院查血沉42 mm/h,ANA1∶320阳性(颗粒型)、ds-DNA、ENA均为阴
Systemic sclerosis is a clinically localized or diffuse skin thickening and fibrosis characterized by connective tissue disease, can affect the heart, lung, kidney, digestive tract and other systems. Scleroderma renal crisis (SRC) is one of the most critical complication of systemic sclerosis visceral damage, most of the prognosis is poor. A case of SRC is reported and reviewed. 1 Clinical data Female patients, aged 58, due to repeated Raynaud’s phenomenon with the skin hard 9 months, headache, nausea, anorexia 3 d admission. After 9 months of upper respiratory tract infection, both hands turned cold and numbness, numbness, finger and facial skin gradually harden. A month ago in the outer hospital check blood sedimentation 42 mm / h, ANA1: 320 positive (particle type), ds-DNA, ENA are yin