本文介绍了靶向腺病毒与传统腺病毒载体相比之优势以及两种不同的靶向腺病毒构建策略。靶向腺病毒需要满足两个条件 ,一是去除天然嗜性 ,二是靶向新受体。有两种途径可以达到这一目的。“双组分体系”中 ,腺病毒与双特异分子结合 ,该双特异分子可同时去除天然嗜性和靶向新受体。“单组分体系”中 ,病毒颗粒经基因修饰后 ,不再与天然受体结合 ,并加入了新配基。双组分体系可灵活地通过某特异受体而达到靶向效果 ,单组分体系则更适于作为基因治疗药物 This article describes the advantages of targeting adenoviruses over traditional adenoviral vectors and two different strategies for targeting adenoviruses. Targeted adenovirus needs to meet two conditions, one is to remove the natural tropism, the second is to target new receptors. There are two ways to accomplish this. In the “two-component system”, adenovirus binds to bispecific molecules that remove both natural tropism and new receptors. In the “one-component system”, the virus particles are genetically modified to no longer bind to the native receptor and incorporate neo-ligands. Two-component system can be flexible through a specific receptor to achieve the target effect, one-component system is more suitable as a gene therapy drug