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198 9～ 1997年间 ,对 48例不能切除的肝细胞癌每次用大剂量顺铂 (CDDP) 12 0 m g～ 16 0 m g、丝裂霉素 (MMC) 10 m g～2 0 m g作肝动脉灌注。治疗后症状缓解 90 % ,肿瘤缩小 36 .8% ,甲胎蛋白恢复正常或明显下降 85 %。获随访 40例 ,尚生存 2 9例 ,半年生存率 5 7.5 % ,1年生存率 2 7.5 % ,最长 2 2个月仍生存。依本文的临床观察 ,按作者等的用法与用量 ,虽有一定的消化道反应、造血抑制及肝脏毒性 ,但多不严重 ,不影响治疗 ,无明显肾毒性
198 Between 1997 and 1997, 48 cases of unresectable hepatocellular carcinoma were treated with high-dose cisplatin (CDDP) 120 mg to 160 mg and mitomycin (MMC) 10 mg to 20 mg for hepatic artery perfusion. . After treatment, symptoms were relieved by 90%, tumors shrank by 36.8%, and alpha-fetoprotein returned to normal or significantly decreased by 85%. Followed up 40 cases, still surviving 29 cases, half-year survival rate of 5 7.5 percent, 1 year survival rate of 27.5 percent, the longest 22 months still survive. According to the clinical observation of this article, according to the author’s usage and dosage, although there is a certain degree of digestive tract reaction, hematopoietic inhibition and hepatotoxicity, but it is not serious, does not affect the treatment, no significant nephrotoxicity