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目的探讨降钙素原在小儿中枢神经系统感染鉴别诊断中的应用效果。方法 60例小儿中枢神经系统感染患儿作为研究对象,根据患儿感染类型分为细菌性感染组(27例)和病毒性感染组(33例),对所有患儿进行血常规、脑脊液白细胞及血清降钙素水平测定,对比两组患儿的检测结果。结果细菌性感染组患儿脑脊液白细胞计数(1.33±1.28)×10~9/L、脑脊液蛋白(2.34±2.18)g/L、血清降钙素原水平(14.35±9.41)ng/L高于病毒性感染组(0.17±0.08)×10~9/L、(0.71±0.64)g/L、(0.57±0.35)ng/L,差异有统计学意义(P<0.05)。但细菌性感染组患儿脑脊液白细胞计数、脑脊液蛋白水平与病毒性感染组存在数据范围重叠,但两组患儿血清降钙素原水平无数据重叠。结论降钙素原在小儿中枢神经系统感染鉴别诊断中具有良好的应用效果和价值,可推广应用。
Objective To investigate the application of procalcitonin in the differential diagnosis of children with central nervous system infection. Methods Sixty children with central nervous system infection were divided into bacterial infection group (n = 27) and viral infection group (n = 33) according to the type of infection in children. All the children underwent routine blood tests, cerebrospinal fluid leukocytes Serum calcitonin levels were measured, compared with two groups of children test results. Results The counts of CSF (1.33 ± 1.28) × 10 ~ 9 / L, cerebrospinal fluid (2.34 ± 2.18) g / L and serum procalcitonin level (14.35 ± 9.41) ng / L were higher than those of the virus (0.17 ± 0.08) × 10 ~ 9 / L, (0.71 ± 0.64) g / L and (0.57 ± 0.35) ng / L, respectively. The difference was statistically significant (P <0.05). However, the data of cerebrospinal fluid white blood cell count, cerebrospinal fluid protein and viral infection in children with bacterial infection overlapped with each other, but there was no overlap in serum procalcitonin levels between the two groups. Conclusions Procalcitonin has a good effect and value in the differential diagnosis of children with central nervous system infection and can be popularized and applied.