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P物质通过与神经激肽1受体(NK1)结合在感觉和认知过程中发挥着重要的作用。已知P物质可由伤害性初级传入纤维释放,激活含有NK1的投射神经元,从而在脊髓传递伤害性信息的过程中起重要作用。
Substance P plays an important role in sensory and cognitive processes by binding to neurokinin 1 receptor (NK1). It is known that substance P is released by nociceptive primary afferent fibers and activates projection neurons containing NK1, which play an important role in transmitting nociceptive information to the spinal cord.