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包虫病由于其在全球的广泛分布，已经成为一个世界性的公共卫生问题。自 ８０ 年代初由世界卫生组织协调的多中心临床研究，证实苯并咪唑类的阿苯达唑和甲苯达唑对包虫病有效以来，打破了传统的外科手术疗法，开创了包虫病的化疗。经过临床比较，认为阿苯达唑的疗效优于甲苯达唑，但由于阿苯达唑的胃肠道吸收差，导致其生物利用度低，治愈率仅 ３０％ 左右，故包虫病的化疗尚待改进和完善，为此，近年来一些学者致力于改善阿苯达唑生物利用度或筛选新药的实验研究，以期提高包虫病的化疗效果。即一方面通过改进阿苯达唑的剂型，提高其生物利用度和疗效。脂质体载体具有靶向和缓释的作用，利用脂质体，特别是免疫脂质体制备的阿苯达唑剂型，无论是提高疗效，或是降低不良反应，均有明显的效果。而用多聚交酯微粒载体制备成的阿苯达唑针剂，因避开了肠道给药时的吸收问题，对提高阿苯达唑的生物利用度亦非常有效，虽然此种针剂还存在有不足之处，但已为寻求阿苯达唑的非肠道给药疗法进行了有益的尝试。另一方面，将阿苯达唑与吡喹酮、西咪替丁、二肽甲基酯、阿苯达唑亚砜、左旋咪唑及地塞米松等多种化合物分别伍用，均能获得增强阿苯达唑抗包虫作用的效果。吡喹酮本身为一种广谱抗蠕虫药，对棘球蚴的原头?
Echinococcosis has become a worldwide public health problem because of its widespread distribution around the world. Since multicenter clinical studies coordinated by the World Health Organization in the early 1980s that benzodiazepines albendazole and mebendazole have been shown to be effective against echinococcosis, traditional surgical therapies have been broken and echinococcosis has been initiated Chemotherapy. After clinical comparison, that the effect of albendazole is superior to mebendazole, but due to poor absorption of albendazole gastrointestinal tract, resulting in low bioavailability, the cure rate is only about 30%, so the hydatid disease chemotherapy To be improved and perfected, for this reason, in recent years, some scholars have devoted themselves to improving the bioavailability of albendazole or screening new drugs in order to improve the therapeutic effect of hydatid disease. That is, on one hand, the bioavailability and efficacy of albendazole are improved by improving the dosage form of albendazole. The liposome carrier has the effect of targeting and sustained release. The use of the albendazole dosage form prepared by liposomes, especially immunoliposomes, has obvious effects both in improving the curative effect and reducing the adverse reaction. However, the preparation of albendazole injection with polylactide particle carrier is also very effective in improving the bioavailability of albendazole because it avoids the problem of absorption during enteral administration, although such injections still exist There are some shortcomings, but some beneficial attempts have been made for the parenteral administration of albendazole. On the other hand, the combination of albendazole with praziquantel, cimetidine, dipeptidyl ester, albendazole sulfoxide, levamisole and dexamethasone, respectively, Effect of albendazole against hydatid effect. Praziquantel itself is a broad-spectrum anthelmintic, the original head of hydatid cyst?