幽门螺杆菌(H.pylori)和非甾体类抗炎药(NSAID)已被公认为消化性溃疡病两个最主要的病因,但越来越多的证据表明非H.pylori和非NSAID溃疡占消化性溃疡的比例正逐渐增加,可能与H.pylori感染率降低、胆汁反流以及一些少见的高酸、高胃泌素分泌综合征等因素有关。本文综述这一类溃疡的病因、流行病学、发病机制和治疗等方面的研究情况。 H. pylori and non-steroidal anti-inflammatory drugs (NSAIDs) have been recognized as the two most important causes of peptic ulcer disease, but there is increasing evidence that non-H.pylori and non-NSAID ulcers Accounting for the proportion of peptic ulcer is increasing, may be associated with lower H.pylori infection, bile reflux and some rare high acid, high gastrin secretion syndrome and other factors. This article reviews the etiology, epidemiology, pathogenesis and treatment of this type of ulcer.